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《医学前沿(英文)》 doi: 10.1007/s11684-023-1022-x
关键词: acute promyelocytic leukemia plasma proteomics plasma metabolomics cross-sectional correlation network pathogenesis treatment
《化学科学与工程前沿(英文)》 2022年 第16卷 第12期 页码 1751-1760 doi: 10.1007/s11705-022-2211-x
关键词: ARTP mutagenesis Bacillus licheniformis poly-γ-glutamic acid metabolomics
Progress in NMR-based metabolomics of
Qifang PAN,Jingya ZHAO,Yuliang WANG,Kexuan TANG
《农业科学与工程前沿(英文)》 2015年 第2卷 第3期 页码 195-204 doi: 10.15302/J-FASE-2015063
关键词: Catharanthus roseus monoterpenoid indole alkaloids NMR metabolomics
《环境科学与工程前沿(英文)》 2023年 第17卷 第1期 doi: 10.1007/s11783-023-1604-5
● Metabolomic temporal profiling of cells exposed to xenobiotics.
关键词: Metabolomics BPA MCF-7 Temporal profiling Metabolic adaption Dysregulation correlation
ZHANG Huilan, WANG Daowen
《医学前沿(英文)》 2008年 第2卷 第1期 页码 11-14 doi: 10.1007/s11684-008-0003-4
Metabolomics in human type 2 diabetes research
null
《医学前沿(英文)》 2013年 第7卷 第1期 页码 4-13 doi: 10.1007/s11684-013-0248-4
The high prevalence of diabetes and diabetic complications has caused a huge burden on the modern society. Although scientific advances have led to effective strategies for preventing and treating diabetes over the past several decades, little progress has been made toward curing the disease or even getting it under control, from a public health and overall societal standpoint. There is still a lack of reliable biomarkers indicative of metabolic alterations associated with diabetes and different drug responses, highlighting the need for the development of early diagnostic and prognostic markers for diabetes and diabetic complications. The emergence of metabolomics has allowed researchers to systemically measure the small molecule metabolites, which are sensitive to the changes of both environmental and genetic factors and therefore, could be regarded as the link between genotypes and phenotypes. During the last decade, the progression made in metabolomics has provided insightful information on disease development and disease onset prediction. Recent studies using metabolomics approach coupled with statistical tools to predict incident diabetes revealed a number of metabolites that are significantly altered, including branched-chain and aromatic amino acids, such as isoleucine, leucine, valine, tyrosine and phenylalanine, as diagnostic or highly-significant predictors of future diabetes. This review summarizes the current findings of metabolomic studies in human investigations with the most common form of diabetes, type 2 diabetes.
关键词: metabolomics type 2 diabetes metabolic pathway mass spectrometry nuclear magnetic resonance (NMR)
Anna Khlyustova, Cédric Labay, Zdenko Machala, Maria-Pau Ginebra, Cristina Canal
《化学科学与工程前沿(英文)》 2019年 第13卷 第2期 页码 238-252 doi: 10.1007/s11705-019-1801-8
血浆代谢组学结合超微弱发光表征早期2型糖尿病的中医证型 Article
何敏, 孙濛濛, Slavik Koval, Roeland Van Wijk, Thomas Hankemeier, Jan Van der Greef, Eduard P.A. Van Wijk, 王梅
《工程(英文)》 2019年 第5卷 第5期 页码 916-923 doi: 10.1016/j.eng.2019.03.011
2型糖尿病(T2DM)的患病率在全球范围内呈迅速上升趋势。因通用干预措施收效甚微,所以疾病研究的重点已经转向个性化策略,特别是疾病的早期阶段的个性化策略。中医基于系统观建立并结合了个性化策略,提高了我们对个性化诊断的认识。从系统生物学的角度,例如将代谢组学与其他系统性诊断方法(如超微弱发光)相结合,可提高对个性化诊断的理解,同时为此类个性化诊疗策略提供生化相关物质基础。在本研究中,我们研究了44名处于2型糖尿病前期的受试者的血浆代谢组学,探讨了基于以下中医亚型进行疾病早期分型的可行性:气阴两虚、气阴两虚挟痰湿、气阴两虚挟血瘀。此外,通过血浆代谢组学和超微弱发光在中医亚分型方面的关系,获得体内生化参数与体外表征参数的关联性信息,从而尝试对疾病亚型分类及判断有更深一步的阐释。结果表明,血浆代谢物的主成分分析揭示了从中医角度划分的2型糖尿病前期不同亚型之间的差异性。对于3种2型糖尿病前期亚型,相对含量较高的脂质(如胆固醇酯和甘油三酯)是鉴别其中之二的重要元素,并且可能与较高的心血管疾病风险相关。血浆代谢组学数据表明,血脂谱是超微弱发光在2型糖尿病亚型分型中收集的重要组成部分。结果表明,2型糖尿病前期的不同中医亚型之间存在代谢差异,可通过血浆代谢物分析来区分这些亚型,血浆代谢组学为系统性超微弱发光体表测量提供了生化参数相关依据。
Kinetic Monte Carlo simulations of plasma-surface reactions on heterogeneous surfaces
Daniil Marinov
《化学科学与工程前沿(英文)》 2019年 第13卷 第4期 页码 815-822 doi: 10.1007/s11705-019-1837-9
关键词: plasma-surface interaction kinetic Monte Carlo plasma nano technology
From plasma to plasmonics: toward sustainable and clean water production through membranes
《化学科学与工程前沿(英文)》 2023年 第17卷 第12期 页码 1809-1836 doi: 10.1007/s11705-023-2339-3
关键词: water treatment membrane-based process plasma treatment plasma polymerization plasmonic light-to-heat conversion
Atomistic simulations of plasma catalytic processes
Erik C. Neyts
《化学科学与工程前沿(英文)》 2018年 第12卷 第1期 页码 145-154 doi: 10.1007/s11705-017-1674-7
Sepsis biomarkers: an omics perspective
null
《医学前沿(英文)》 2014年 第8卷 第1期 页码 58-67 doi: 10.1007/s11684-014-0318-2
Sepsis is a common cause of death in hospitalized patients worldwide. The early detection of sepsis remains a great challenge for clinicians, and delayed diagnosis frequently undermines treatment efforts, thereby contributing to high mortality. Omics technologies allow high-throughput screening of sepsis biomarkers. This review describes currently available and novel sepsis biomarkers in the context of genomics, transcriptomics, proteomics, and metabolomics. The combination of these technologies can help refine the diagnosis of sepsis. This review paper serves as a reference for future studies that employ an integrated, multi-omics approach to disease identification.
关键词: sepsis biomarker genomics transcriptomics proteomics metabolomics
Plasma-catalysis: Is it just a question of scale?
J. Christopher Whitehead
《化学科学与工程前沿(英文)》 2019年 第13卷 第2期 页码 264-273 doi: 10.1007/s11705-019-1794-3
关键词: plasma catalysis plasma-activated catalysis non-thermal plasma CO2 conversion
Submerged arc plasma system combined with ozone oxidation for the treatment of wastewater containing
《环境科学与工程前沿(英文)》 2021年 第15卷 第5期 doi: 10.1007/s11783-020-1384-0
• Submerged arc plasma was introduced in terms of wastewater treatment.
关键词: Thermal plasma Submerged arc plasma Wastewater Ozone Phenol Highly energetic electron
Modelling and diagnostics of multiple cathodes plasma torch system for plasma spraying
Kirsten BOBZIN, Nazlim BAGCIVAN, Lidong ZHAO, Ivica PETKOVIC, Jochen SCHEIN, Karsten HARTZ-BEHREND, Stefan KIRNER, José-Luis MARQUéS, Günter FORSTER
《机械工程前沿(英文)》 2011年 第6卷 第3期 页码 324-331 doi: 10.1007/s11465-011-0125-2
Usage of a multiple-arcs system has significantly improved process stability and coating properties in air plasma spraying. However, there are still demands on understanding and controlling the physical process to determine process conditions for reproducible coating quality and homogeneity of coating microstructure. The main goal of this work is the application of numerical simulation for the prediction of the temperature profiles at the torch outlet for real process conditions. Behaviour of the gas flow and electric arcs were described in a three-dimensional numerical model. The calculated results showed the characteristic triangular temperature distribution at the torch nozzle outlet caused by three electric arcs. These results were compared with experimentally determined temperature distributions, which were obtained with specially developed computed tomography equipment for reconstructing the emissivity and temperature distribution of the plasma jet close to the torch exit. The calculated results related to temperature values and contours were verified for the most process parameters with experimental ones.
关键词: plasma spraying electric arc three-cathode plasma torch numerical simulation computed tomography
标题 作者 时间 类型 操作
Cross-sectional network analysis of plasma proteins/metabolites correlated with pathogenesis and therapeutic
期刊论文
analysis of with enhanced poly--glutamic acid production through atmospheric and room temperature plasma
期刊论文
Time-dependent metabolomics uncover dynamic metabolic adaptions in MCF-7 cells exposed to bisphenol A
期刊论文
Diagnostic evaluation of plasma aldosterone concentration to plasma renin activity ratio in primary aldosteronism
ZHANG Huilan, WANG Daowen
期刊论文
Important parameters in plasma jets for the production of RONS in liquids for plasma medicine: A brief
Anna Khlyustova, Cédric Labay, Zdenko Machala, Maria-Pau Ginebra, Cristina Canal
期刊论文
血浆代谢组学结合超微弱发光表征早期2型糖尿病的中医证型
何敏, 孙濛濛, Slavik Koval, Roeland Van Wijk, Thomas Hankemeier, Jan Van der Greef, Eduard P.A. Van Wijk, 王梅
期刊论文
Kinetic Monte Carlo simulations of plasma-surface reactions on heterogeneous surfaces
Daniil Marinov
期刊论文
Submerged arc plasma system combined with ozone oxidation for the treatment of wastewater containing
期刊论文